Gene information
Official symbol FN1
Official full name fibronectin 1
Gene type protein-coding gene
Chromosome2q35
Alias symbolMSF; CIG; LETS; GFND2; FINC
Gene familyReceptor ligands; Fibronectin type III domain containing
Resources
Entrez Gene 2335
HGNC HGNC:3778
Ensembl ENSG00000115414
Vega OTTHUMG00000133054
UCSC uc002vfa.4
GO terms: 116 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001704 formation of primary germ layer GO Biological Processes -8.70692533 22 More
GO:0001706 endoderm formation GO Biological Processes -7.82381493 14 More
GO:0001755 neural crest cell migration GO Biological Processes -8.06132628 15 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005198 structural molecule activity GO Molecular Functions -7.51921139 30 More
GO:0005201 extracellular matrix structural constituent GO Molecular Functions -12.8379048 20 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005577 fibrinogen complex GO Cellular Components -9.87912674 6 More
GO:0005604 basement membrane GO Cellular Components -9.30297759 21 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO Cellular Components -2.09961494 6 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007160 cell-matrix adhesion GO Biological Processes -9.58867374 15 More
GO:0007229 integrin-mediated signaling pathway GO Biological Processes -5.80936917 16 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0007492 endoderm development GO Biological Processes -8.07123392 17 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008022 protein C-terminus binding GO Molecular Functions -1.51097294 6 More
GO:0008047 enzyme activator activity GO Molecular Functions -1.49794348 13 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008360 regulation of cell shape GO Biological Processes -5.20319448 20 More
GO:0008361 regulation of cell size GO Biological Processes -4.6524989 21 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0014033 neural crest cell differentiation GO Biological Processes -12.2997127 24 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0018149 peptide cross-linking GO Biological Processes -2.91368104 4 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0034109 homotypic cell-cell adhesion GO Biological Processes -7.07578331 9 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0034446 substrate adhesion-dependent cell spreading GO Biological Processes -3.29518609 9 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035987 endodermal cell differentiation GO Biological Processes -8.15231722 13 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0043394 proteoglycan binding GO Molecular Functions -12.1259478 11 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045773 positive regulation of axon extension GO Biological Processes -2.96833359 7 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0048145 regulation of fibroblast proliferation GO Biological Processes -11.1167439 21 More
GO:0048483 autonomic nervous system development GO Biological Processes -4.59833472 10 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050770 regulation of axonogenesis GO Biological Processes -3.56457741 17 More
GO:0050772 positive regulation of axonogenesis GO Biological Processes -1.81127841 8 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051087 chaperone binding GO Molecular Functions -6.81600949 11 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061387 regulation of extent of cell growth GO Biological Processes -3.21598264 13 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070527 platelet aggregation GO Biological Processes -8.40921139 9 More
GO:0072376 protein activation cascade GO Biological Processes -12.3481888 9 More
GO:0072378 blood coagulation, fibrin clot formation GO Biological Processes -12.9665312 9 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0090497 mesenchymal cell migration GO Biological Processes -8.76593708 16 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
Drug-Gene interaction
view
Related drugs: 4 records
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
fibronectin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dyck RF et al. Clin Invest Med. 1990
fibronectin proteomics streptokinase[treatment (pharmacotherapy)] acute myocardial infarction Dyck RF et al. Clin Invest Med. 1990
fibronectin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Laudat A et al. West Indian Med J. 1996
fibronectin proteomics left ventricular thrombus[prognosis (bad)] acute anterior myocardial infarction Orem C et al. Thromb Res. 2002
All rights reserved: Soochow University Center for Systems Biology